| Author | Message | ||
Linkmaster Legend Username: Linkmaster Post Number: 48484 Registered: 02-2008 Posted From: 149.128.8.245 Rating: N/A |
neevu saamnyuduvi kaadu appaaa.. | ||
Starc Junior Artist Username: Starc Post Number: 828 Registered: 03-2015 Posted From: 170.63.120.116 Rating: N/A |
okay babai.. thanks for your inputs. case details: tnbc mid 30s stg 4.. india lo chethulu ettesharu.. emi cheyyalo ardam kavadam ledu.. just reading through articles. | ||
Senapathy Hero Username: Senapathy Post Number: 18067 Registered: 01-2009 Posted From: 137.131.20.144 Rating: N/A |
Annai, ilanti articles chala vasta untayi. Medical journals lo. They usually go positive with their findings. Not to discourage most of them do not result in a therapy. But almost all rationally developed drugs have evolved from a sound scientific background such as this study. Mouse models nundi real life theraphy ki translate cheyyadam is a herculean task. If patients actuallt respond to this gene. My 2 cents. I will check back later at night. Busy today. I am struck by the lightning of love and burnt beyond repair - Florentino Ariza | ||
Starc Junior Artist Username: Starc Post Number: 827 Registered: 03-2015 Posted From: 170.63.120.116 Rating: N/A |
https://unclineberger.org/news/parise-cib1 Is this promising? above link tho nikku details anni ardam avuthai.. so life mida home vadilesukovadamena? | ||
Senapathy Hero Username: Senapathy Post Number: 18066 Registered: 01-2009 Posted From: 137.131.20.144 Rating: N/A |
Mouse genetics are not fully translatable to humans annai. But such data is usually promising and right direction. Monkey models are usually recommended for testing before human clinical trials, but again not a hard and fast rule It might take any where between 10-15 years for a drug from inception to end of clinical trials. Usually each step is a hurdle and can be abandoned at that stage if results are negative If there are already drugs for that pathway (and that protein), it is usually a head start. As pharamco kinetics are already in place. General rule of thumb is most targets are not druggable. Anduke we are always searching for alternate ways. But we have to start somewhere. Hope it helps ! I am struck by the lightning of love and burnt beyond repair - Florentino Ariza | ||
Starc Junior Artist Username: Starc Post Number: 825 Registered: 03-2015 Posted From: 170.63.120.116 Rating: N/A |
cancer | ||
Vasu Side Hero Username: Vasu Post Number: 8898 Registered: 10-2014 Posted From: 47.16.177.98 Rating: N/A |
amyloidosis? Yes, we endorse you..... Edi Chee...anna Evadidi Chee...anna meeke saadhyam  Bala->Jr->Rajni->Mahesh->Prabhas/Rajamouli (Hence Proved) | ||
Kantha_rao Comedian Username: Kantha_rao Post Number: 1103 Registered: 11-2013 Posted From: 12.218.0.70 Rating: N/A |
em disease ? | ||
Starc Junior Artist Username: Starc Post Number: 824 Registered: 03-2015 Posted From: 170.63.120.116 Rating: N/A |
Senapathy, USa lo oka mouse mida research chesi CIB1 protein is cause for the disease and it is proved in mouse ani icchadu.. next the drug trials should go in this direction in human ani cheppadu.. ee stage nunchi 3 phase human trials chesi FDA approval chesi market lo medicine ravadaniki enni samastaralu padutundi? or instead of waiting can we use drugs which are in market already to block this protein? |