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Senapathy
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Username: Senapathy

Post Number: 11707
Registered: 01-2009

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Posted on Monday, July 16, 2012 - 09:34 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

no one is taking advantage of anything




I am talking of it as a whole, not a foreign MNC conducting trials in India.


Farmer:

when there is no foul play




Of the 39 drugs on which information was available, the panel found that in the case of 18 drugs, adequate clinical trials had not been conducted - many of the drugs had been tested on fewer patients and in fewer hospitals than what is legally mandated.

Every month, on average, the authorities say, one drug is approved in India without trials.

The only thing I agree is that the system we made is not efficient.
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Farmer
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Post Number: 3402
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Posted on Monday, July 16, 2012 - 09:15 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Senapathy:

However, I am against all the loopholes taken advantage of in our system. As plain as that.


no one is taking advantage of anything....lack of education in india creates a million problems...this is one of them...problem mana side vundhi...don't cry foul when there is no foul play
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Senapathy
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Post Number: 11706
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Posted on Monday, July 16, 2012 - 08:53 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

moral obligation mana meedha vundaa ledaaa? etantaav




Thadu mottam clear gaa saduvu.

I am not against clinical trials. Anywhere. It is a necessary part of sustaining our race.

However, I am against all the loopholes taken advantage of in our system. As plain as that.
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Farmer
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Posted on Monday, July 16, 2012 - 08:49 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Senapathy:

Idi pakkana petti, India lo trials meeda nee view ettu antey ettav. Why?


naa view separate gaa pettedhi emundii..it is very obvious...

phase 1 is not allowed, as our govt has apprehensions...

phase 2 and 3 are allowed...case katham dukaan bandh...of course participants kii explain cheyyali...not easy in india, because of lack of education....

now answer my question...vere countries loo develop chesi, test chesi, prove aina drugs ni manam vichalavidigaa vaadukuntunnappudu, trials loo enthoo kontha participate cheyyalsina moral obligation mana meedha vundaa ledaaa? etantaav
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Senapathy
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Post Number: 11705
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Posted on Monday, July 16, 2012 - 08:43 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

inkoncham latest ikkada chaduvkoo...




Latest news India 1971, China 3047 and USA 62,575

Idi pakkana petti, India lo trials meeda nee view ettu antey ettav. Why?
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Farmer
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Post Number: 3399
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Posted on Monday, July 16, 2012 - 08:35 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Senapathy:

&sanman,






Farmer:

data released by the US National Institutes of Health (USNIH)



Farmer:

Dr Surinder Singh, drug controller general of India


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Farmer
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Post Number: 3398
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Posted on Monday, July 16, 2012 - 08:33 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Senapathy:

India lo ~250, China lo ~320. Nee point ento sooti gaa seppu..



adhi 2010 news...inkoncham latest ikkada chaduvkoo...

http://articles.timesofindia.indiatimes.com/2011-02-05/india /28362377_1_clinical-trials-registry-ctri-trials-account

India is far behind US and China when it comes to hosting global clinical trials, contrary to popular belief. According to data released by the US National Institutes of Health (USNIH), India is currently hosting 1,400 clinical trials compared to 52,107 in the US and 7,356 in China.

Globally, the number of trials underway stands at 1.02 lakh. In an exclusive interview to TOI, Dr Surinder Singh, drug controller general of India, said India was far from becoming the world's clinical trials hub. "It's a myth," he said.
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Sanman
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Post Number: 6838
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Posted on Monday, July 16, 2012 - 08:31 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

aaa companies china and other countries loo chese dhanitho polisthe, india loo chesedhi almost negligible


are you saying this data is incorrect ?
that shows about 20% difference between china and India, not negligible
http://www.independent.co.uk/incoming/article6262008.ece/ALT ERNATES/w460/Pg-2-victims.jpg
prajaa court - http://imgur.com/2Z3Kx
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Senapathy
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Posted on Monday, July 16, 2012 - 08:27 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

aaa companies china and other countries loo chese dhanitho polisthe, india loo chesedhi almost negligible




India lo ~250, China lo ~320. Nee point ento sooti gaa seppu..

Ur view of clinical trials in India.
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Farmer
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Posted on Monday, July 16, 2012 - 08:22 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)

http://www.business-standard.com/india/news/clinical-trials- losingplot-in-india/419660/
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Farmer
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Posted on Monday, July 16, 2012 - 08:20 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

time fashion


timely
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Farmer
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Posted on Monday, July 16, 2012 - 08:19 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)

next, contrary to popular opinion...india is not really a hot bed for multinational pharma companies to conduct trials....majority of the companies ishta padavu cheyyatam.....because..people don't turn up properly and in a time fashion for followup..etc....aaa companies china and other countries loo chese dhanitho polisthe, india loo chesedhi almost negligible
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Farmer
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Posted on Monday, July 16, 2012 - 08:17 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Sanman:


also, look at it from the other side...oka american company thanu develop chesina drug ni india loo test chesi (stage 2 and stage 3), results ni thaaru maaru chesi, fda approval thesthe, evariki nashtam? american people kii...because they will start production of the drug and they will sell it to american people
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Farmer
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Post Number: 3392
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Posted on Monday, July 16, 2012 - 08:14 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Sanman:


also, developing nations looo jaruguthunna trials and harmful effects ani evadanna news vesthe, you should not necessarily think they are talking about india....Reason: stage 1 is not allowed in India, as i mentioned before
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Sanman
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Post Number: 6837
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Posted on Monday, July 16, 2012 - 08:11 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:


thank you for the technical details. i think the thread topic is about moral implications of big pharma doing trials in poor countries where regulation is lax and expense is cheap, the implication being life is cheaper in poorer countries. 80% of US drug trials are done overseas
prajaa court - http://imgur.com/2Z3Kx
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Posted on Monday, July 16, 2012 - 08:07 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Sanman:


Stage 1: drug pani chesthundaa ledhaa ani test cheyyavu...drug emanna harm chesthundaa cheyyadaa ani test chestavu..

stage 1 looo fail aithe (ante harmful ani prove aithe) aaa drug stage 2 ki velladhu

stage 2 and stage 3: drug aaa particular disease kii pani chestundaa ledhaa anedhi test chestav...for example, lung cancer ki develop chesina drug aithe, lung cancer patients meedha test chestaav...

stage 2 kii, stage 3 kii koncham chinna chinna differences vuntai....again stage 2 loo fail aithe stage 3 kii velladhu...stage 3 loo fail aithe stage 4 kii velladhu

stage 4- postmarketing research and continued monitoring for any side effects..

stage 1 clinical trials by multi national pharmas on drugs developed outside India are NOT allowed in India...so drug safe ani vere countries loo janala meedha prove ainaake, India ki vastaru, for stage 2
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Sanman
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Post Number: 6836
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Posted on Monday, July 16, 2012 - 08:03 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

atlage phase 2 and phase 3 clinical trials have to be done on the approporiate population group...psych drug ni aaa particular psych condition vunna valla meedha test cheyyali...pillalaki vadalsina mandulani pillala meedha test cheyyali...anthe kaani nee meedha cheyyaru


aahaa does that explain this ?
http://www.independent.co.uk/incoming/article6262008.ece/ALT ERNATES/w460/Pg-2-victims.jpg
evado vere desam vaadiki unna concern mana metta batch ki lekapovadam too worst
http://www.naturalnews.com/031109_drug_trials_developing_nat ions.html
The drug industry refers to developing country trial recruits as "drug-naive patients" because they usually are not being treated for any condition nor taking any medications. Such patients are almost sure to yield better test results. The term could also apply to how uninformed the patients are. In many instances, patients are led to believe they are being given a medicine to help them and do not understand that it is experimental or that they may be getting a placebo. Consent may consist of only a thumbprint or scrawled "X".

It is much easier to avoid FDA and other institutional scrutiny and sweep negative trial results - including deaths - under the rug in developing countries. In 2008, the FDA inspected only 0.7 percent of all overseas trial sites. That`s just 45 out of the 6,485 locations.
prajaa court - http://imgur.com/2Z3Kx
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Farmer
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Post Number: 3390
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Posted on Monday, July 16, 2012 - 08:00 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Sanman:

bongule raaka raaka nee field lo matlaade oka chance vasthe telisindhi share chesukokunda thed lo migilina vaallane karustunnaavu asalu topic endhi nee sodhi endhi kindha link post chesaanu daani gurinchi emanna cheppedhi unte eduvu



Farmer:

first, u need to understand how clinical trials are structured, before u make ill informed remarks...
clinical trials have 3 stages, and phase 1 is the most dangerous of them all...that is where u test whether a drug is safe or not....u do not test the efficacy in phase 1....phase 2 and 3 are done to test whether the drug works....phase 2 and 3 are relatively very safe...India does NOT allow phase 1 clinical trials on drugs that are developed outside India, by multi national companies....

atlage phase 2 and phase 3 clinical trials have to be done on the approporiate population group...psych drug ni aaa particular psych condition vunna valla meedha test cheyyali...pillalaki vadalsina mandulani pillala meedha test cheyyali...anthe kaani nee meedha cheyyaru


ok..nuvvu first ee post chaduvu...eee post loo neeku artham kaani vishayam emanna vunte adugu...matladadam...then we will take it slowly from there, in an orderly fashion...btw, naaki yee pharma nunchi paisa ante paisa raadhu
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Farmer
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Posted on Monday, July 16, 2012 - 07:57 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Sanman:

ee thed lo unna same field knowledgeable batch probably getting salary from one of those drug companies.


ohooo... ippudu eee angle try chestunnava...gawd bless ammaa
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Sanman
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Posted on Monday, July 16, 2012 - 07:57 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

dobbehee...clinical trials gurinchi neeku enduku mari...vaati structure kooda theliyakundaa same questions malli malli adigi sava dobbuthav....prathi topic meedha matter lekundaa edava gola...pakkaki elli guns meedha thedd eskoni akkada aadukooo


bongule raaka raaka nee field lo matlaade oka chance vasthe telisindhi share chesukokunda thed lo migilina vaallane karustunnaavu asalu topic endhi nee sodhi endhi kindha link post chesaanu daani gurinchi emanna cheppedhi unte eduvu
prajaa court - http://imgur.com/2Z3Kx
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Farmer
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Post Number: 3388
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Posted on Monday, July 16, 2012 - 07:56 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Senapathy:

Bench and clinical topic tessindhi nuvvu.


adhi neetho kaadu....sanman ki cheppanu...ninnu edhooo personal gaa anesinattu nuvvu enduku oogavoo artham kaledhu

Senapathy:

Nuvvu thindi ki banda paakuru gaani try sestunnava?


kinda nunchi paiki oka saari thread malli chaduvkooo...enjoy...bye
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Sanman
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Posted on Monday, July 16, 2012 - 07:56 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)

ee thed lo unna same field knowledgeable batch probably getting salary from one of those drug companies. if you really want to know how poor are exploited in trials, read these articles
http://www.independent.co.uk/news/world/asia/without-consent -how-drugs-companies-exploit-indian-guinea-pigs-6261919.html
Since restrictions on drug trials were relaxed in 2005, the industry in India has swollen to the point where today more than 150,000 people are involved in at least 1,600 clinical trials, conducted on behalf of British, American and European firms including AstraZeneca, Pfizer, and Merck. There may be more.
see how the poorest nations of the world are ideal candidates for testing
http://www.independent.co.uk/incoming/article6262008.ece/ALT ERNATES/w460/Pg-2-victims.jpg
prajaa court - http://imgur.com/2Z3Kx
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Farmer
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Posted on Monday, July 16, 2012 - 07:54 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Sanman:

mind dobbindha edho background unnattundhi topic midha neeku telisindhe right annattu saava dobbutunnavu endhuku India Africa lo human trials chestai ante answer teliyadhu edhava nasa


dobbehee...clinical trials gurinchi neeku enduku mari...vaati structure kooda theliyakundaa same questions malli malli adigi sava dobbuthav....prathi topic meedha matter lekundaa edava gola...pakkaki elli guns meedha thedd eskoni akkada aadukooo
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Senapathy
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Posted on Monday, July 16, 2012 - 07:53 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Senapathy:




On a different note this is the sad state of regulation of waste

http://www.nature.com/news/2009/090204/full/457640a.html
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Senapathy
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Posted on Monday, July 16, 2012 - 07:51 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

this thread is not about bench vs clinical




Bench and clinical topic tessindhi nuvvu.

Anyway ee link kooda saduvu

http://www.bbc.co.uk/news/world-asia-india-18018158
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Sanman
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Posted on Monday, July 16, 2012 - 07:41 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

aapehee sodhii...phase 1 trials by multinational pharmas is prohibited in india.....clinical trials are totally different from bench research, done on guinea pigs or guinea pandulu..or guinea rodents...whatever...clinical trials meedha koncham background chaduvkoni repu kanapadu..


mind dobbindha edho background unnattundhi topic midha neeku telisindhe right annattu saava dobbutunnavu endhuku India Africa lo human trials chestai ante answer teliyadhu edhava nasa
prajaa court - http://imgur.com/2Z3Kx
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Senapathy
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Posted on Monday, July 16, 2012 - 07:39 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Ipc302:

anduke mana desam vaipu




India lo clinical trials lekunda drugs legally administered. Alanti oka lax system vasthey MNC's enduku use seskov adhyaccha
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Senapathy
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Posted on Monday, July 16, 2012 - 07:38 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

ok..so let's not develop drugs anymore...hehehe






Nuvvu thindi ki banda paakuru gaani try sestunnava?
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Ipc302
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Posted on Monday, July 16, 2012 - 07:28 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Senapathy:

http://www.medicalnewstoday.com/articles/247341.php




aa link chadiva...takkuva penalty esaru ani janalu booths dobbuthunnaru..
merck ki ilage oka drug ki fatalities unnayi ani chala pedda penalty esaru...anduke mana desam vaipu dobbukosthunnaru due to lax laws, bribe and get out any situation system...
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Senapathy:

For me its simple - any combination of atoms that can help you, can also harm you.


ok..so let's not develop drugs anymore...hehehe
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Posted on Monday, July 16, 2012 - 07:26 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Senapathy:



Nee tenki.

Aa WHO report is not correct ani June lo publish seasru raa babooo ani vinipinchukovu emi. Naa posi 11686 sadivava?


neee dash...who statistics thappu ani evadooo cheppaledhu...vallu question chesedhi Ap and gujarat loo kakundaa vere states aithe better emoo ani...and proper follow up services levu ani...

ainaa oka very ordinary journal looo padina article pattukoni who statistics thappu ani oogaku


Senapathy:

I know it was well as any expert in the field.


ok..good for u

Senapathy:

Yes we know. But always know no bench, no clinical trial.


yeah..and vice versa too...no meaning whatsoever for bench research, if it doesn't translate into something clinical...this thread is not about bench vs clinical..don't divert the topic to please your ego
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Senapathy
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Posted on Monday, July 16, 2012 - 07:24 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Ipc302:

sesthe kinda shrink ayipoyindhi




Shrink kaadu ehe, fuse out anta. Not for all though. But I would like to be informed before I take any drug.

Also bear in mind that the long term effect of each drug, vaccine is subjective. Objective results are not considered as each clinical trial does not go beyond an ear.

For me its simple - any combination of atoms that can help you, can also harm you.

Alst week oka link esha. Idi soodu

http://www.medicalnewstoday.com/articles/247341.php

(Message edited by senapathy on July 16, 2012)
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Ipc302
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why don't people understand that such false/ unprofessional studies are going to come and bite us in our azz. There is no use for such studies when the patients have no benefit. Monna propecia case lo netti meedha unna bochu length increase kosam mandu use sesthe kinda shrink ayipoyindhi...endho antha maaya
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Senapathy
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Farmer:




Anyway farmer saab, light teesko. I do not want to say anything against doctors. For me, they hold very high respect.

Kaani India lo unethical practices meeda we all are on same page. That is necessary.
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Senapathy
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Ipc302:

malaria trials




Yaa. India lo TB and malaria are the hot beds. Gates gaaru paisal baaga daarapostunnar
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Senapathy
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Farmer:

inka statistics kii aaa who report chaduvkoo.




Nee tenki.

Aa WHO report is not correct ani June lo publish seasru raa babooo ani vinipinchukovu emi. Naa posi 11686 sadivava?


Farmer:

vaccine ki outcome measure cheyyatam enduku kashtam, drug ki enduku easy anedhaani meedha alochinchu




I know it was well as any expert in the field.


Farmer:

bench research kii clinical trials kii day and night difference vundhi ani




Yes we know. But always know no bench, no clinical trial.
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Farmer
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Senapathy:

Nayana, nenu vaccine sesi isthey, nuvvu administer sesi log book maintain settav, Naaku seppa maaku.


kikik...anduke cheppaa...bench research kii clinical trials kii day and night difference vundhi ani...
btw, vaccine ki outcome measure cheyyatam enduku kashtam, drug ki enduku easy anedhaani meedha alochinchu....parledhu...we all need food for thought at times..

inka statistics kii aaa who report chaduvkoo....anyways, neeku ego hurt ayinattu vundhi...i'm out
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Ipc302
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mana desam lo malaria trials sesthunnara lekapothe cancer trials fr pharma companies ena
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Farmer
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Senapathy:


India lo leni diseases ki kooda mana meeda clinical trials enduku?


India has a population of 366.58 millions women ages 15 years and older who are at risk of developing cervical cancer. Current estimates indicate that every year 134420 women are diagnosed
with cervical cancer and 72825 die from the disease. Cervical cancer ranks as the 1st most frequent
cancer among women in India, and the 1st most frequent cancer among women between 15 and 44
years of age. About 7.9% of women in the general population are estimated to harbour cervical HPV
infection at a given time., and 82.5% of invasive cervical cancers are attributed to HPVs 16 or 18.
http://apps.who.int/hpvcentre/statistics/dynamic/ico/country _pdf/IND.pdf

WHO report from 2010....number one cancer in indian women, age groups 15 to 44...meaning "Young women"....adhi matter
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Senapathy
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Farmer:

endukooo neeku artham avvali...artham kakapothe, gawd bless




Nayana, nenu vaccine sesi isthey, nuvvu administer sesi log book maintain settav, Naaku seppa maaku.
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Senapathy
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Farmer:

statistic choosukooo




Link etti matladu. You need to look at % incidence as a ratio of population.

I am not completely against HPV trials in India. They are not done properly.

India lo leni diseases ki kooda mana meeda clinical trials enduku? More info kavalantey seppu link istha
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Ipc302
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Senapathy:

Farmer kurrod link aduguthad emo kaani, inda idi saduv




farmer kurrod ni oggeyyi
mana desam lo ethical responsibility in science anedhi chala takkuva...informed consent from parents undali anna vishayam kooda hide chestharu...i bet they lie to those kids saying that its is a vaccine and not a trial...we are hopelessly corrupt, incompetent in these kind of things...full disclosure undadhu ilanti vishayam lo...and no body gives a damn about explaining these things to the people who sign up for trial...emundhi trial lo participate chesthe dabbul isthamu ani cheppi velimudra veyyinchukuni trial start chestharu...adhi informed consent stage mana desam lo..gawd bless
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Senapathy:


Farmer kurrod link aduguthad emo kaani, inda idi saduv

http://www.nature.com/news/2011/110622/full/474427a.html



Farmer:

..inka out comes measure cheyyatam anedhi drug ki easy, vaccine ki chala kashtam....endukooo neeku artham avvali...artham kakapothe, gawd bless


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Sanman:

do you have data about how many of these companies are subsidiaries of foreign companies ? do you know why a lot of US pharma companies do trials in India and Africa ?


aapehee sodhii...phase 1 trials by multinational pharmas is prohibited in india.....clinical trials are totally different from bench research, done on guinea pigs or guinea pandulu..or guinea rodents...whatever...clinical trials meedha koncham background chaduvkoni repu kanapadu..
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Senapathy
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Ipc302:



Farmer kurrod link aduguthad emo kaani, inda idi saduv

http://www.nature.com/news/2011/110622/full/474427a.html
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Senapathy:


Nee talakaay,


neee tenkaii..millions ante millions ani kaadhu..a lot of people ani...india has a very high incidence of cervical cancer...statistic choosukooo....theliyakundaa notiki vachinattu matladaku...and the incidence is particularly high in rural women..anduke valla meedha test chesaaru....inka out comes measure cheyyatam anedhi drug ki easy, vaccine ki chala kashtam....endukooo neeku artham avvali...artham kakapothe, gawd bless
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Senapathy
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Ipc302:

I bet the people who were participants in these trials never even heard about informed consent




HPV case lo, the school head master was signing forms for the vaccine anta. That is our stage of informed content.
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Ipc302
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Senapathy:

There is nothing wrong in pharma companies saving money, provided the same protocol is applied everywhere.




the protocol has to the same according to FDA rules. But you never know if these rules will be applied in those countries. It is so hard to get approval from ethics boards when planning for a clinical trial. So many rules make sure that patients are not forced by doctors, drug companies into participating for a clinical trial. It is the integrity of a hospital, doctor that comes into question when such things happen. SO they take enough precautions to avoid fatalities, law suits. Mana desam lo aa scene ledhu.
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Sanman
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Farmer:

atlage phase 2 and phase 3 clinical trials have to be done on the approporiate population group...psych drug ni aaa particular psych condition vunna valla meedha test cheyyali...pillalaki vadalsina mandulani pillala meedha test cheyyali...anthe kaani nee meedha cheyyaru


do you have data about how many of these companies are subsidiaries of foreign companies ? do you know why a lot of US pharma companies do trials in India and Africa ?
prajaa court - http://imgur.com/2Z3Kx
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Sanman:

if the trials are being done by foreign companies, that is the message they are sending. they need to explain the consequences to participants . that news article said trials were being done on mentally handicapped people, babies, etc.
for multinational pharmaceuticals it is cheap lab rats and no regulations make India and africa attractive options


first, u need to understand how clinical trials are structured, before u make ill informed remarks...
clinical trials have 3 stages, and phase 1 is the most dangerous of them all...that is where u test whether a drug is safe or not....u do not test the efficacy in phase 1....phase 2 and 3 are done to test whether the drug works....phase 2 and 3 are relatively very safe...India does NOT allow phase 1 clinical trials on drugs that are developed outside India, by multi national companies....

atlage phase 2 and phase 3 clinical trials have to be done on the approporiate population group...psych drug ni aaa particular psych condition vunna valla meedha test cheyyali...pillalaki vadalsina mandulani pillala meedha test cheyyali...anthe kaani nee meedha cheyyaru
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Senapathy
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Ipc302:

reduce the expenditure for human trials




U nailed it. There is nothing wrong in pharma companies saving money, provided the same protocol is applied everywhere.

How can u educate a tribal woman of what is being done to her. To her, doctor is a god.
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Ipc302
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Sanman:

that news article said trials were being done on mentally handicapped people, babies, etc.




This is over simplifying the fact. Some drugs intended for mental and neo natal diseases have to tested on kids and mental health patients. SO you have to conduct on them. The difference is you have to give the patient all the information and the choice to opt in or opt out of the trial. I bet the people who were participants in these trials never even heard about informed consent. We cut too many corners to earn money and that ends up making our lives cheaper.
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Ipc302
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The care that has to be taken to inform, approval of patients participating in clinical trials is negligible in India compared to USA. I don't even think poeple have a clue about how to form an ethics board when approving a clinical trial. Feels like Big pharma is dumping the clinical trials to reduce the expenditure for human trials. not just now since the late 1990's even pharma dept in AU were accused of forcing students to volunteer for trials of drugs. Yeah yeah everybody gets the importance of clinical trials but what is the point of conducting trials when you end up killing people, misinformation, blatant negligence. Clinical trials, ethical regualtions, informed consent all these go hand in hand. we are sorely lacking in the last two depts but want to make money of the trials.
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Senapathy
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Farmer:

4 deaths "attributed" to hpv vaccine trials..."attributed" not "proven"....




This is not the case I am asking for. In the HPV case, a clinical outcome for these 4 girls was never estimated. Antey they did not bother to check. PATH director himself confirmed this. Quoting from a nature article

"PATH believes that the HPV vaccine study under review was not a 'clinical' trial because no clinical outcomes were measured."


Farmer:

cervical cancer was killing millions of indians every year....go figure..lol




Nee talakaay, millions kaadu. Anywhere from 1-2 lacs per annum. Nuvvu nee hype.
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Senapathy
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Farmer:




Paper published last month in JRSM stating that India is poor target for HPV trials. WHO will now revise its claim.

The Indian government suspended research in April 2010 on the feasibility and safety of human papillomavirus (HPV) vaccine in two Indian states (Andhra Pradesh and Gujarat) amid public concerns about its safety. This paper describes cervical cancer and cancer surveillance in India and reviews the epidemiological claims made by the Programme for Appropriate Technology in Health (PATH) in support of the vaccine in these two states. National cancer data published by the Indian National Cancer Registry Programme of state registry returns and the International Agency for Research on Cancer cover around seven percent of the population with underrepresentation of rural, northern, eastern and north-eastern areas. There is no cancer registry in the state of Andhra Pradesh and PATH does not cite data from the Gujarat cancer registries. Age-adjusted cervical cancer mortality and incidence rates vary widely across and within states. National trends in age standardized cervical cancer incidence fell from 42.3 to 22.3 per 100,000 between 1982/1983 and 2004/2005 respectively. Incidence studies report low incidence and mortality rates in Gujarat and Andhra Pradesh. Although HPV prevalence is higher in cancer patients (93.3%) than healthy patients (7.0%) and HPV types 16 and 18 are most prevalent in cancer patients, population prevelance data are poor and studies highly variable in their findings. Current data on HPV type and cervical cancer incidence do not support PATH's claim that India has a large burden of cervical cancer or its decision to roll out the vaccine programme. In the absence of comprehensive cancer surveillance, World Health Organization criteria with respect to monitoring effectiveness of the vaccine and knowledge of disease trends cannot be fulfilled.
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Farmer:

india will benefit hugely from hpv vaccine...but trials matram india loo cheyyodhu...vere chota chesi, prove ainaka, manam aa benefits enjoy cheyochu


if the trials are being done by foreign companies, that is the message they are sending. they need to explain the consequences to participants . that news article said trials were being done on mentally handicapped people, babies, etc.
for multinational pharmaceuticals it is cheap lab rats and no regulations make India and africa attractive options
prajaa court - http://imgur.com/2Z3Kx
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Senapathy:

if I am correct 4 deaths were attributed to this case.


4 deaths "attributed" to hpv vaccine trials..."attributed" not "proven"....

and cervical cancer was killing millions of indians every year....go figure..lol

india will benefit hugely from hpv vaccine...but trials matram india loo cheyyodhu...vere chota chesi, prove ainaka, manam aa benefits enjoy cheyochu
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strange that a govt that protects its citizens from second hand smoke, plastic usage, bad language in movies, controversial books, hurt feelings etc does not give a crap about nuclear waste, hospital conditions, school conditions, water pollution, air pollution and being used as lab rats for clinical trials
on a side note guinea pigs do not belong to pig family so literal translation is not warranted. guinea pandhulu ani eenadu vaari prayogam daridram gaa undhi
prajaa court - http://imgur.com/2Z3Kx
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Senapathy:

Why was HPV vaccine trials done in Indis when the biggest risk group is USA. And what about tribal girls in AP and Gujarat used for this purpose. if I am correct 4 deaths were attributed to this case.




http://articles.timesofindia.indiatimes.com/2012-02-04/mumba i/31024533_1_cervical-cancer-breast-cancer-globocan

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Mental_sachinodu:

hmm ante new medicine ante thiffal thappav .. adhe ancient, devudu davirect ga seppad panisesthadhi ani septhe, no trials needed kadha daatar gaaru


innii dasabdhalugaa research motham west lone jarigindhi..clinical trials koodaa west loo janala meedhe jariginiyyi..and we have reaped the benefits of that research...ippudu india loo koodaa chesthante, thattukovatam kashtam gaa vundhi.....
of course, clinical trials lekundaa, jaundice vachina pillalaki chethula meeda vaathalu pettukuntaa enjoy seyochu
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Farmer:

who is "we"?




Nenu and DB lo already disco jarigindi


Farmer:

but asalu mana desam loo clinical trials yee cheyyakoodadhu, janalni vaadukoo koodadhu ante kudaradhu antunnaa




Alaa cehyaakodadu ani neni enduku antaa. Prathi daniki oka paddathi untadi. I do not support the use of population for vaccination trials, drug trials for no risk groups.

Why was HPV vaccine trials done in Indis when the biggest risk group is USA. And what about tribal girls in AP and Gujarat used for this purpose. if I am correct 4 deaths were attributed to this case.
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Farmer:

but asalu mana desam loo clinical trials yee cheyyakoodadhu, janalni vaadukoo koodadhu ante kudaradhu antunnaa




hmm ante new medicine ante thiffal thappav .. adhe ancient, devudu davirect ga seppad panisesthadhi ani septhe, no trials needed kadha daatar gaaru
the world of appearances may or may not be real, or both may and may not be real - or may be indescribable; or may be real and indescribable, or unreal and indescribable; or in the end may be read and unreal and indescribable - its all Syadvada
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Senapathy:

We are talking about unethical practices.


who is "we"?
unethical ani prove chesi close cheyinchali..no problem....but asalu mana desam loo clinical trials yee cheyyakoodadhu, janalni vaadukoo koodadhu ante kudaradhu antunnaa
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Senapathy
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Posted on Monday, July 16, 2012 - 05:34 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

of course, akramamgaa chesthe thappe




We are talking about unethical practices.
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Farmer
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Posted on Monday, July 16, 2012 - 04:23 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Senapathy:

Akkada ragam eti nee talam enti. Nee nundi inka vere emi egaspect sestham daatar saab


clinical trials manushula meeda kaaka pandula meeda chestara? of course, akramamgaa chesthe thappe..but media pulihora kooda baane vuntundi indialoo, ilanti vishayalloo...clinical trials prapancham loo anni desallonu jaruguthaii, including usa
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Pulibongaram
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Posted on Monday, July 16, 2012 - 04:18 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Methati_idly:

nenu anedi alaa ollu gulla seyinchukune candidates min aa matram kuda alochinchara ani



akkadiki velle vallaki anni details septhaaru anukuntunnaavaa leka vaallaki iche forms vaallu sadavagalaru anukuntunnaavaa?
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Senapathy
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Posted on Monday, July 16, 2012 - 04:09 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

clinical trials are necessary




Akkada ragam eti nee talam enti. Nee nundi inka vere emi egaspect sestham daatar saab
I am struck by the lightning of love and burnt beyond repair - Florentino Ariza

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Thelegend
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Posted on Monday, July 16, 2012 - 03:59 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Methati_idly:

idoka pedda mafia type


oh yeah, mudupulu, lobbylu channa chachhayi ee pharma batch ki konni state govts tho
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Thelegend
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Posted on Monday, July 16, 2012 - 03:58 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Farmer:

clinical trials are necessary


adhi correcte, alaa ani konda batch ni fafam manushulni lab rats cheseyakkodadu ganda
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Methati_idly
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Posted on Monday, July 16, 2012 - 03:47 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Thelegend:

#1 avi em testso, side effects ento vallaki teliyavu
#2 money


yaa ade, monna chusa tv show..idoka pedda mafia type, ikkada saala farma kempenies ki manollu rats ni supply sesinattu same candidates ni repeated ga multiple drugs ki using

nenu anedi alaa ollu gulla seyinchukune candidates min aa matram kuda alochinchara ani
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Farmer
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Posted on Monday, July 16, 2012 - 03:42 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)

media pulihora ekkuva india looo....clinical trials are necessary
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Thelegend
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Posted on Monday, July 16, 2012 - 03:38 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)


Methati_idly:

aina clinical trails ki ela veltaru asalu..too much



#1 avi em testso, side effects ento vallaki teliyavu
#2 money
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Methati_idly
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Posted on Monday, July 16, 2012 - 03:36 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)

aina clinical trails ki ela veltaru asalu..too much
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Thelegend
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Posted on Monday, July 16, 2012 - 03:21 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)

sad state of some unfortunate people in desam analemo. Becuase somebody is making money for sure in desam from this
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Thelegend
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Posted on Monday, July 16, 2012 - 03:20 pm:   Insert Quote Edit PostDelete PostPrint Post   Move Post (Moderator/Admin Only)Ban Poster IP (Moderator/Admin only)

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