| Author | Message | ||
     Bushu Side Hero Username: Bushu Post Number: 2567 Registered: 04-2009 Posted From: 12.30.230.138 Rating: N/A |
endhidhi geek and latrine laagundhi. damn it. bi p c theeskunnollu kooda baagu padi pothunnaru gaa  | ||
| Ipc302 Moderator Username: Ipc302 Post Number: 8607 Registered: 02-2008 Rating: N/A |
tubulin is not in the lysosomal structure AFAIK...CD30 is a tumor necrosis family receptor | ||
| Venkateswarlu Side Hero Username: Venkateswarlu Post Number: 8789 Registered: 01-2010 Posted From: 67.168.29.210 Rating: N/A |
Eseyyi ippatnunde.. If you know little basics of programming, kummeyyi. Complete the certification - Base, Advanced and Clinical. Three levels. Not hard at all. And you will have good career in SAS and BioTech. If you are good in Statistics, you will hit the jackpot. Manchigaa nerchukoni touch lo undu.. I might be able to hire you into our team.. lets go.. In this db, there's always someone watching you!!  | ||
| Ishan Moderator Username: Ishan Post Number: 9088 Registered: 01-2009 Rating: N/A |
I meant to say the activated enzyme will be released from the lysosome and destroys tubulin. I dont think tubulin is actually present inside the lysosome in functional form. Perhaps its just signal transduction pathway. I think CD30 is TFNalfaReceptor - which activates NF-kB, which is important for apoptosis. I am not sure of the exact mechanism though | ||
| Chinnu Side Hero Username: Chinnu Post Number: 4736 Registered: 05-2010 Posted From: 69.136.255.138 Rating: N/A |
Bro, SAS gurinchi chinna clarification  I am into Pharma field and Grad next yr ki complete avtadi and I am planning to learn SAS aswell ..So naa doubt entante ippudu nerchukovatam best aa ? Lekpothe last sem lo nerchukovatam best aa ? Ippudu summer lo kaali ga unna kada anii I am thinking on taking it ..Advice ivvagalaru ..TIA Entha peaks ki ellam aneedi kaadu, em peeekam aneedi important ! .. Em peekaru antee jenda peekam antaaremo ! | ||
| Ipc302 Moderator Username: Ipc302 Post Number: 8606 Registered: 02-2008 Rating: N/A |
cell biology area naadhi....function of genes especially integrin related and their role in gonad development so r u related to drug development | ||
| Venkateswarlu Side Hero Username: Venkateswarlu Post Number: 8787 Registered: 01-2010 Posted From: 67.168.29.210 Rating: N/A |
Both. Programmer for biotech.. In this db, there's always someone watching you!! | ||
| Venkateswarlu Side Hero Username: Venkateswarlu Post Number: 8786 Registered: 01-2010 Posted From: 67.168.29.210 Rating: N/A |
Thank you dollin's.. inga tirugu ledu manaki ee knowledge thoti.. Mee mee research areas ettandi.. Currently we are attacking Non-Hodgkin lymphoma.. In this db, there's always someone watching you!! | ||
| Ipc302 Moderator Username: Ipc302 Post Number: 8605 Registered: 02-2008 Rating: N/A |
is there any advantage to targeting tubulin in the lysosome when the entire structure can be destroyed in the lysosome | ||
| Ishan Moderator Username: Ishan Post Number: 9087 Registered: 01-2009 Rating: N/A |
thats the job of lysosome. Anything that is unusual on the cell surface will be consumed by lysosomes and destroyed. | ||
| Secondcup Comedian Username: Secondcup Post Number: 1818 Registered: 02-2008 Posted From: 199.74.155.50 Rating: N/A |
Venkay nuvvu kooda BIO-tech ? SAS meeda working ani cheppinatlu gurthu. | ||
| Ishan Moderator Username: Ishan Post Number: 9086 Registered: 01-2009 Rating: N/A |
drug and CD30 combine ayyaaka the combo will be phagoctized by the lysosomes and inside the lysosomes perhaps they activate a tubulin specific enzyme which will cleave tubulins thus killing the network. lysosomes are very important organelles. They are enzyme banks and recycle many junk materials...its like a junk yard machine | ||
| Senapathy Side Hero Username: Senapathy Post Number: 4745 Registered: 01-2009 Posted From: 137.131.212.40 Rating: N/A |
Adi natural course mama.. Food tinte stomach loki poyinattu, cell surface gets phagocytosed and the resulting endosomes will become lysosomes to kill all the debris. @ Chinnu - Grad aa? Which Univ? I am struck by the lightning of love and burnt beyond repair - Florentino Ariza | ||
| Ipc302 Moderator Username: Ipc302 Post Number: 8604 Registered: 02-2008 Rating: N/A |
well the simplest way for a cell to destroy foreign material or any cellular material is through lysosomes...so u r drug is attaching itself to tuuor cells through the CD30 and destroying it by channeling it to the lysosomal compartments | ||
| Venkateswarlu Side Hero Username: Venkateswarlu Post Number: 8785 Registered: 01-2010 Posted From: 67.168.29.210 Rating: N/A |
Yeah.. I like reading study related docs..  In this db, there's always someone watching you!! | ||
| Venkateswarlu Side Hero Username: Venkateswarlu Post Number: 8784 Registered: 01-2010 Posted From: 67.168.29.210 Rating: N/A |
This is where my confusion is. Explain this: The binding of ADC [anti body drug conjugate] to CD30 on the cell surface initiates internalization of ADC-CD30 complex, which then traffics to lysosomal compartment. I am clear on adc recognizing cd30 positive cell etc. Why 'traffics to lysosomal compartment'?? In this db, there's always someone watching you!! | ||
| Idiot1 Junior Artist Username: Idiot1 Post Number: 536 Registered: 07-2008 Posted From: 199.245.32.210 Rating: N/A |
neeku  ni set cheyyali raa appudu kaani daarloki raavu | ||
| Chinnu Side Hero Username: Chinnu Post Number: 4735 Registered: 05-2010 Posted From: 69.136.255.138 Rating: N/A |
... student anna nen inkaa ..Entha peaks ki ellam aneedi kaadu, em peeekam aneedi important ! .. Em peekaru antee jenda peekam antaaremo ! | ||
| Idiot1 Junior Artist Username: Idiot1 Post Number: 535 Registered: 07-2008 Posted From: 199.245.32.210 Rating: N/A |
nuvvu raamudu manchi baaludu type lo mottham docs anni sadivestava? | ||
| Senapathy Side Hero Username: Senapathy Post Number: 4744 Registered: 01-2009 Posted From: 137.131.212.40 Rating: N/A |
What company yaa.. What position? Nice to know.. I am struck by the lightning of love and burnt beyond repair - Florentino Ariza | ||
| Senapathy Side Hero Username: Senapathy Post Number: 4743 Registered: 01-2009 Posted From: 137.131.212.40 Rating: N/A |
Roju 4 shakeela sinemalu choodu. All set Contact Sagar baa for more details I am struck by the lightning of love and burnt beyond repair - Florentino Ariza | ||
| Chinnu Side Hero Username: Chinnu Post Number: 4733 Registered: 05-2010 Posted From: 69.136.255.138 Rating: N/A |
Microtubules meeda effect untadi anukunta kada ?
Me into pharma drugs Entha peaks ki ellam aneedi kaadu, em peeekam aneedi important ! .. Em peekaru antee jenda peekam antaaremo ! | ||
| Senapathy Side Hero Username: Senapathy Post Number: 4742 Registered: 01-2009 Posted From: 137.131.212.40 Rating: N/A |
Thats a natural way for cells to intake any foreign molecule. Most of the foreign molecules near cellular surface are phagocytosed http://en.wikipedia.org/wiki/Phagocytosis The debris end up in lysosomes that have acidic pH. My gut peeling is that the acidic pH in lysosomes might act on ur drug. May be urs is a pro-drug and needs activation in lysosomes/endosomes. My 2 cents. I am struck by the lightning of love and burnt beyond repair - Florentino Ariza | ||
| Zingthing Junior Artist Username: Zingthing Post Number: 373 Registered: 01-2011 Posted From: 98.110.225.222 Rating: N/A |
undi. If you are not married, get married. If you are already married, get a stepney. | ||
| Ipc302 Moderator Username: Ipc302 Post Number: 8603 Registered: 02-2008 Rating: N/A |
steroids teesuko ..vezy ga janalni kottochu | ||
| Ipc302 Moderator Username: Ipc302 Post Number: 8601 Registered: 02-2008 Rating: N/A |
venki lysosomes are organelles that break up the cellular waste...are u saying that the drug disrupts the microtubular network in the lysosomes... if so what function does that achieve? are u not destroying the lysosomes microtubular network is essentail during cell cycle for functions such as mitosis and cytokinesis by performing contractile functions... so in effect disrupting the mtubules leads to loss of cell division and eventually cell death/ apoptosis...also mtubules are part of braoder network of cytoskeleton of cell.... | ||
| Senapathy Side Hero Username: Senapathy Post Number: 4741 Registered: 01-2009 Posted From: 137.131.212.40 Rating: N/A |
Post doc.. Biomed anukovacchu What abt u yaaa? I am struck by the lightning of love and burnt beyond repair - Florentino Ariza | ||
| Venkateswarlu Side Hero Username: Venkateswarlu Post Number: 8782 Registered: 01-2010 Posted From: 67.168.29.210 Rating: N/A |
Yes.. we harvest mAb's and we target CD30 and 70. My question is, lysosome lopatki poyi, how the drug kills the microtubular network? If at all want to kill a cell, instead of going inside an oranelle why not stay inside the cell and kill it.. Lysosome function endi ani ethikithe, its like a trash can.. Not sure how Paclitaxel works.. but similar family.. Adcetris is our trade name.. In this db, there's always someone watching you!! | ||
| Chitti_v2 Junior Artist Username: Chitti_v2 Post Number: 829 Registered: 01-2011 Posted From: 160.83.73.18 Rating: N/A |
annaa....ee majjana rojuu rojanthaa thikka thikkagaa untaandi.......madusulandarni kotti avathala paaranookadaam anifisthaandi.....deeniki edannaa mondu undaa? | ||
| Chinnu Side Hero Username: Chinnu Post Number: 4730 Registered: 05-2010 Posted From: 69.136.255.138 Rating: N/A |
Biotech aa ? Entha peaks ki ellam aneedi kaadu, em peeekam aneedi important ! .. Em peekaru antee jenda peekam antaaremo ! | ||
| Senapathy Side Hero Username: Senapathy Post Number: 4739 Registered: 01-2009 Posted From: 137.131.212.40 Rating: N/A |
partially yes.. ippudu mAb and vaccines kooda.  I am struck by the lightning of love and burnt beyond repair - Florentino Ariza | ||
| Chinnu Side Hero Username: Chinnu Post Number: 4729 Registered: 05-2010 Posted From: 69.136.255.138 Rating: N/A |
Meeru research cheesedi drugs meeda naa ? Entha peaks ki ellam aneedi kaadu, em peeekam aneedi important ! .. Em peekaru antee jenda peekam antaaremo ! | ||
| Ishan Moderator Username: Ishan Post Number: 9084 Registered: 01-2009 Rating: N/A |
Dolling I didnt know you are in Bio too. CDs are surface proteins on various immune related cells - they act like markers for cells. mAB therapy lo they target individual cell types via these markers. | ||
| Senapathy Side Hero Username: Senapathy Post Number: 4737 Registered: 01-2009 Posted From: 137.131.212.40 Rating: N/A |
Are u working on a variant of Paclitaxel? Apotposis ki main route is through caspase activation. Aa angle lo alosiddari.. I am struck by the lightning of love and burnt beyond repair - Florentino Ariza | ||
| Senapathy Side Hero Username: Senapathy Post Number: 4736 Registered: 01-2009 Posted From: 137.131.212.40 Rating: N/A |
Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs Read the paper with above title. This ss the current review for cell behaviour for antimitotic and perturbation of microtubular network in cells. Access lekunte email ettu. pdf mail sesthaa I am struck by the lightning of love and burnt beyond repair - Florentino Ariza | ||
| Venkateswarlu Side Hero Username: Venkateswarlu Post Number: 8780 Registered: 01-2010 Posted From: 67.168.29.210 Rating: N/A |
Sena: How does disrupting microtubular network within cell leads to apoptosis? Infact, the drug we researching on.. enters into CD30 cell and then is directed to lysosomal compartment.. within this compartment, it disrupts the mtubular network.. Idiot: Mana researchii ide.. konni study protocols saduvutunte burra heat ekki potundi.. sagam sagam ardham ayyi.. but very very interesting.. asalu mana human body ranze endo telustundi.. In this db, there's always someone watching you!! | ||
| Senapathy Side Hero Username: Senapathy Post Number: 4735 Registered: 01-2009 Posted From: 137.131.212.40 Rating: N/A |
Just idea undhi.. Kaani detail gaa teliyadu. May be Ishan dorling knows I am struck by the lightning of love and burnt beyond repair - Florentino Ariza | ||
| Idiot1 Junior Artist Username: Idiot1 Post Number: 533 Registered: 07-2008 Posted From: 199.245.32.210 Rating: N/A |
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| Venkateswarlu Side Hero Username: Venkateswarlu Post Number: 8777 Registered: 01-2010 Posted From: 67.168.29.210 Rating: N/A |
mAb therapies and Cluster of Differentiation meeda idea undaa meeku? In this db, there's always someone watching you!! |
